(4aS;8aR)-NPD-001
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HY-150025-1EACH
About this Product
- SKU:
- HY-150025
- Application:
- Antibody Microarray
- CAS Number:
- 2366272-43-5
- Extra Details:
- (4aS;8aR)-NPD-001 is a potent and allosteric inhibitor of DNMT3A. (4aS;8aR)-NPD-001 inhibits DNMT3A activity by disrupting protein-protein interactions. (4aS;8aR)-NPD-001 induces apoptosis of acute myeloid leukemia (AML) cell lines. (4aS;8aR)-NPD-001 induces differentiation of distinct AML cell lines including cells with mutated DNMT3A R882[1].
- Molecular Weight:
- 584.71
- References:
- [1]Sandoval JE, et al. First-in-Class Allosteric Inhibitors of DNMT3A Disrupt Protein-Protein Interactions and Induce Acute Myeloid Leukemia Cell Differentiation. J Med Chem. 2022 Jul 22.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
