BWA-522
Product Sizes
5 mg
£ POA
HY-149433-5MG
10 mg
£ POA
HY-149433-10MG
1 mg
£ POA
HY-149433-1MG
10mM/1mL
£ POA
HY-149433-10MM
50 mg
£ POA
HY-149433-50MG
100 mg
£ POA
HY-149433-100MG
25 mg
£ POA
HY-149433-25MG
About this Product
- SKU:
- HY-149433
- Application:
- Antibody Microarray
- CAS Number:
- 3042820-12-9
- Extra Details:
- BWA-522 is an orally active PROTAC degrader targeting full-length androgen receptor (AR-FL) and androgen receptor splice variant 7 (AR-V7). BWA-522 antagonizes the N-terminal domain (AR-NTD) of the androgen receptor; suppresses AR downstream signaling proteins and induces cancer cells apoptosis. BWA-522 inhibits tumor growth in LNCaP xenograft mouse model. BWA-522 can be used for the research of prostate cancer[1].
- Molecular Weight:
- 771.34
- Purity:
- 98.04
- References:
- [1]Zhang B, et al. Discovery of BWA-522, a First-in-Class and Orally Bioavailable PROTAC Degrader of the Androgen Receptor Targeting N-Terminal Domain for the Treatment of Prostate Cancer. J Med Chem. 2023 Aug 24;66(16):11158-11186..
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Apoptosis;Vitamin D Related/Nuclear Receptor
