5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)
Product Sizes
25 mg
£ POA
HY-148503-25MG
100 mg
£ POA
HY-148503-100MG
50 mg
£ POA
HY-148503-50MG
About this Product
- SKU:
- HY-148503
- Application:
- Antibody Microarray
- CAS Number:
- 1197033-19-4
- Extra Details:
- 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer used to synthesize locked nucleic acid (LNA) analog oligonucleotides. It can be used as a building block of antisense oligonucleotides (ASOs) to target complementary RNA sequences. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) locks the furanose ring into an N-type conformation through 2';4'-constrained ethyl (cEt) modification; enhancing hybridization affinity and mismatch discrimination with RNA; while significantly improving the resistance of oligonucleotides to exonuclease digestion. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) mediates RNase H-dependent mRNA degradation or inhibits translation by forming a stable hybrid with RNA; thereby achieving gene expression regulation. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is mainly used in the development of antisense drugs; gene function research and oligonucleotide synthesis related to disease treatment[1][2].
- Molecular Weight:
- 899.97
- Purity:
- 98.55
- References:
- [1]Seth PP, et al. Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues. J Org Chem. 2010 Mar 5;75(5):1569-81.|[2]Vasquez G, et al. Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs. Nucleic Acids Res. 2021 Feb 26;49(4):1828-1839.
- Research Area:
- Others
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C (Powder; stored under nitrogen; away from moisture)
- Type:
- Molecular Biology Reagents: Nucleic Acids
- Pathway:
- Cell Cycle/DNA Damage
