Lirafugratinib (hydrochloride)
Product Sizes
10 mg
£ POA
HY-147250A-10MG
100 mg
£ POA
HY-147250A-100MG
25 mg
£ POA
HY-147250A-25MG
5 mg
£ POA
HY-147250A-5MG
50 mg
£ POA
HY-147250A-50MG
10mM/1mL
£ POA
HY-147250A-10MM
About this Product
- SKU:
- HY-147250A
- Additional Names:
- RLY-4008 (hydrochloride)
- CAS Number:
- 2688040-45-9
- Extra Details:
- Lirafugratinib (RLY-4008) hydrochloride is an orally active; irreversible and highly selective FGFR2 inhibitor with an IC50 of 3 nM. Lirafugratinib hydrochloride covalently binds to Cys491. Lirafugratinib hydrochloride targets FGFR2 primary alterations and resistance mutations and induces tumor regression while sparing other FGFRs[1].
- Molecular Weight:
- 546.00
- Purity:
- 98.96
- References:
- [1]Vivek Subbiah, et al. RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations. Cancer Discov. 2023 Sep 6;13(9):2012-2031.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Protein Tyrosine Kinase/RTK
