HS-276
Product Sizes
100 mg
£ POA
HY-147141-100MG
10 mg
£ POA
HY-147141-10MG
5 mg
£ POA
HY-147141-5MG
50 mg
£ POA
HY-147141-50MG
25 mg
£ POA
HY-147141-25MG
About this Product
- SKU:
- HY-147141
- CAS Number:
- 2767422-72-8
- Extra Details:
- HS-276 is an orally active; potent and highly selective TAK1 inhibitor; with a Ki of 2.5 nM. HS-276 shows significant inhibition of TAK1; CLK2; GCK; ULK2; MAP4K5; IRAK1; NUAK; CSNK1G2; CAMKKβ-1; and MLK1; with IC50 values of 8.25; 29; 33; 63; 125; 264; 270; 810; 1280; and 5585 nM; respectively. HS-276 can be used for rheumatoid arthritis (RA) research[1].
- Molecular Weight:
- 419.52
- Purity:
- 98.93
- References:
- [1]Scarneo S, et al. Development and Efficacy of an Orally Bioavailable Selective TAK1 Inhibitor for the Treatment of Inflammatory Arthritis. ACS Chem Biol. 2022 Mar 18;17(3):536-544.
- Research Area:
- Inflammation/Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C; 3 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Apoptosis;Cell Cycle/DNA Damage;Immunology/Inflammation;Stem Cell/Wnt
