SK-575-NEG
Product Sizes
5 mg
£ POA
HY-147101-5MG
About this Product
- SKU:
- HY-147101
- Application:
- Antibody Microarray
- CAS Number:
- 2523017-04-9
- Extra Details:
- SK-575-NEG (compound 28); a methylation counterpart of SK-575; is synthesized by methylation of the amino group of piperidine-2;6-dione in SK-575 as an control compound. SK-575-NEG is strongly bound to PARP1; with an IC50 of 2.64 nM. SK-575-NEG was completely ineffective in inducing PARP1 degradation in MDA-MB-436 and Capan-1 cells at concentrations up to 1 μM[1].
- Molecular Weight:
- 891.00
- References:
- [1]Cao C, et al. Discovery of SK-575 as a Highly Potent and Efficacious Proteolysis-Targeting Chimera Degrader of PARP1 for Treating Cancers. J Med Chem. 2020 Oct 8;63(19):11012-11033.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Cell Cycle/DNA Damage;Epigenetics
