AS 1411 (sodium)
Product Sizes
1 mg
£ POA
HY-147081A-1MG
10 mg
£ POA
HY-147081A-10MG
5 mg
£ POA
HY-147081A-5MG
About this Product
- SKU:
- HY-147081A
- Additional Names:
- AGRO-100 (sodium)
- Application:
- Antibody Microarray
- Extra Details:
- AS 1411 (AGRO-100) sodium is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 sodium inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles; oligonucleotides and small molecules to cancer cells. AS 1411 sodium reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. S 1411 sodium works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. S 1411 sodium-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models; has the ability to cross the blood-brain barrier with low tissue toxicity[1][2][3]
- Molecular Weight:
- 8272.31
- Purity:
- 99.52
- References:
- [1]Teng Y, et al. AS1411 alters the localization of a complex containing protein arginine methyltransferase 5 and nucleolin. Cancer Res. 2007;67(21):10491-10500. |[2]Soundararajan S, et al. The nucleolin targeting aptamer AS1411 destabilizes Bcl-2 messenger RNA in human breast cancer cells. Cancer Res. 2008;68(7):2358-2365.
- Research Area:
- Cancer
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C (Powder; sealed storage; away from moisture)
- Type:
- Molecular Biology Reagents: Nucleic Acids
- Pathway:
- Cell Cycle/DNA Damage
