Agatolimod
Product Sizes
10 mg
£ POA
HY-146244-10MG
5 mg
£ POA
HY-146244-5MG
1 mg
£ POA
HY-146244-1MG
About this Product
- SKU:
- HY-146244
- Additional Names:
- ODN 2006; PF-3512676; CpG 7909; ODN 7909
- CAS Number:
- 525625-52-9
- Extra Details:
- Agatolimod ((ODN 2006; PF-3512676; CpG 7909)) is a TLR9 agonist and immunomodulator with an EC50 of 180 nM against human TLR9. Agatolimod activates and upregulates the expression of both TLR9 and TLR6; and mediates downstream signaling pathways via IRAK4; IRF5; IRF7. Agatolimod induces Th1-type innate and adaptive immune responses; activates various immune cells and promotes antigen presentation; regulates antibody levels and immune cell infiltration; upregulates the secretion of multiple cytokines; induces apoptosis and cell cycle arrest; enhances cytotoxicity; and clears intracellular Salmonella. Agatolimod is applicable to research on COVID?19; breast cancer; lung adenocarcinoma; HPV-related tumors; melanoma; and salmonellosis[1][2][3][4][5].
- Molecular Weight:
- 7699
- Purity:
- 98.84
- References:
- [1]Xie H, et al. CpG-induced immunomodulation and intracellular bacterial killing in a chicken macrophage cell line. Dev Comp Immunol. 2003 Oct;27(9):823-34.|[2]Babaer D, et al. Oligodeoxynucleotides ODN 2006 and M362 Exert Potent Adjuvant Effect through TLR-9/-6 Synergy to Exaggerate Mammaglobin-A Peptide Specific Cytotoxic CD8+T Lymphocyte Responses against Breast Cancer Cells. Cancers (Basel). 2019 May 14;11(5):672.
- Research Area:
- Cancer;Infection
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C (Powder; sealed storage; away from moisture)
- Type:
- Molecular Biology Reagents: Nucleic Acids
- Pathway:
- Immunology/Inflammation
