(3R;10R;14aS)-AZD4625
Product Sizes
10 mg
£ POA
HY-146223A-10MG
25 mg
£ POA
HY-146223A-25MG
5 mg
£ POA
HY-146223A-5MG
1 mg
£ POA
HY-146223A-1MG
10mM/1mL
£ POA
HY-146223A-10MM
About this Product
- SKU:
- HY-146223A
- Application:
- Antibody Microarray
- Extra Details:
- (3R;10R;14aS)-AZD4625 is the isomer of AZD4625 (HY-146223); and can be used as an experimental control. AZD4625 is an orally active; selective irreversible; covalent allosteric GTPase KRASG12C inhibitor with an IC50 of 3 nM. AZD4625 can inhibit the MAPK pathway (with decreased pCRAF; pMEK; and pERK) and the PI3K pathway (with decreased pAKT and pS6); and induce cell apoptosis. AZD4625 has no binding and inhibition of wild-type RAS or isoforms carrying non-KRASG12C mutations. AZD4625 can be used for the study of KRASG12C mutant non-small cell lung cancer[1][2].
- Molecular Weight:
- 486.90
- Purity:
- 98.00
- References:
- [1]Kettle JG, et al. Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C. J Med Chem. 2022 May 12;65(9):6940-6952.
- Research Area:
- Cancer
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C; 3 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- GPCR/G Protein;MAPK/ERK Pathway
