5A2-SC8
Product Sizes
5 mg
£ POA
HY-145799-5MG
10 mg
£ POA
HY-145799-10MG
1 mg
£ POA
HY-145799-1MG
100 mg
£ POA
HY-145799-100MG
25 mg
£ POA
HY-145799-25MG
50 mg
£ POA
HY-145799-50MG
About this Product
- SKU:
- HY-145799
- CAS Number:
- 1857341-90-2
- Extra Details:
- 5A2-SC8 is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity; enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 LNPs can confer a unique delivery fate of RNA within the liver; thereby changing the therapeutic outcomes in cancer models[1][2][3].
- Molecular Weight:
- 1841.72
- Purity:
- 99.89
- References:
- [1]Zhou K, Nguyen LH, Miller JB, et al. Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model. Proc Natl Acad Sci U S A. 2016;113(3):520-525. |[2]Johnson, et al. "Lipid nanoparticle (LNP) chemistry can endow unique in vivo RNA delivery fates within the liver that alter therapeutic outcomes in a cancer model." Molecular pharmaceutics 19.11 (2022): 3973-3986.|[3]Johnson, et al. The Impact of Lipid Nanoparticle Chemistry on RNA Delivery and Therapeutic Outcomes. Diss. 2022.
- Research Area:
- Cancer
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C (Powder; protect from light; stored under nitrogen)
- Type:
- Molecular Biology Reagents: Nucleic Acids
- Pathway:
- Metabolic Enzyme/Protease
