Apatorsen
Product Sizes
10 mg
£ POA
HY-145722A-10MG
5 mg
£ POA
HY-145722A-5MG
1 mg
£ POA
HY-145722A-1MG
About this Product
- SKU:
- HY-145722A
- Additional Names:
- OGX-427
- Application:
- Antibody Microarray
- CAS Number:
- 1002331-21-6
- Extra Details:
- Apatorsen is a 2'-methoxyethyl-modified antisense oligonucleotide and also a Hsp27 inhibitor. Apatorsen reduces Hsp27 mRNA and protein levels; impairs stress-induced cytoprotective functions; induces cell apoptosis; inhibits tumor growth and prevents metastasis. Apatorsen is applicable to research related to non-small cell lung cancer; castration-resistant prostate cancer; breast cancer; ovarian cancer and bladder cancer[1][2].
- Molecular Weight:
- 7157.00
- Purity:
- 98.54
- References:
- [1]Spigel DR, Shipley DL, Waterhouse DM, et al. A Randomized, Double-Blinded, Phase II Trial of Carboplatin and Pemetrexed with or without Apatorsen (OGX-427) in Patients with Previously Untreated Stage IV Non-Squamous-Non-Small-Cell Lung Cancer: The SPRUCE Trial. Oncologist. 2019;24(12):e1409-e1416. |[2]Yu EY, Ellard SL, Hotte SJ, et al. A randomized phase 2 study of a HSP27 targeting antisense, apatorsen with prednisone versus prednisone alone, in patients with metastatic castration resistant prostate cancer. Invest New Drugs. 2018;36(2):278-287.
- Research Area:
- Cancer
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C (Powder; sealed storage; away from moisture)
- Type:
- Molecular Biology Reagents: Nucleic Acids
- Pathway:
- Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
