Apatorsen (sodium)
Product Sizes
5 mg
£ POA
HY-145722-5MG
1 mg
£ POA
HY-145722-1MG
10 mg
£ POA
HY-145722-10MG
About this Product
- SKU:
- HY-145722
- Additional Names:
- OGX-427 (sodium)
- Application:
- Antibody Microarray
- CAS Number:
- 915443-09-3
- Extra Details:
- Apatorsen (OGX-427) sodium is a 2'-methoxyethyl-modified antisense oligonucleotide and also a Hsp27 inhibitor. Apatorsen sodium reduces Hsp27 mRNA and protein levels; impairs stress-induced cytoprotective functions; induces cell apoptosis; inhibits tumor growth and prevents metastasis. Apatorsen sodium is applicable to research related to non-small cell lung cancer; castration-resistant prostate cancer; breast cancer; ovarian cancer and bladder cancer[1][2].
- Molecular Weight:
- 7157 (free acid)
- Purity:
- 98.54
- References:
- [1]Yu EY, Ellard SL, Hotte SJ, et al. A randomized phase 2 study of a HSP27 targeting antisense, apatorsen with prednisone versus prednisone alone, in patients with metastatic castration resistant prostate cancer. Invest New Drugs. 2018;36(2):278-287. |[2]Spigel DR, Shipley DL, Waterhouse DM, et al. A Randomized, Double-Blinded, Phase II Trial of Carboplatin and Pemetrexed with or without Apatorsen (OGX-427) in Patients with Previously Untreated Stage IV Non-Squamous-Non-Small-Cell Lung Cancer: The SPRUCE Trial. Oncologist. 2019;24(12):e1409-e1416.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; sealed storage; away from moisture)
- Type:
- Molecular Biology Reagents: Nucleic Acids
- Pathway:
- Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
