BSJ-02-162
Product Sizes
25 mg
£ POA
HY-144995-25MG
50 mg
£ POA
HY-144995-50MG
10 mg
£ POA
HY-144995-10MG
5 mg
£ POA
HY-144995-5MG
100 mg
£ POA
HY-144995-100MG
10mM/1mL
£ POA
HY-144995-10MM
About this Product
- SKU:
- HY-144995
- Additional Names:
- CDK4/6-IN-11
- CAS Number:
- 2139329-47-6
- Extra Details:
- CDK4/6-IN-11 is a potent PROTAC CDK4/6 degrader[1]. CDK4/6-IN-11 consists of a thalidomide-based E3 ligase ligand (blue part) Thalidomide-NH-CH2-COOH (HY-131717); a target protein ligand (red part) Palbociclib (HY-50767); and a PROTAC linker (black part) Boc-NH-C4-Br (HY-W007803). E3 ligase ligand and linker can form Thalidomide-NH-amido-C4-Br (HY-170307).
- Molecular Weight:
- 831.92
- Purity:
- 98.07
- References:
- [1]Nathanael S. Gray, et al. Degradation of cyclin-dependent kinase 4/6 (cdk4/6) by conjugation of cdk4/6 inhibitors with e3 ligase ligand and methods of use. WO2020023480 A1.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Cell Cycle/DNA Damage;PROTAC
