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Proteins and Peptides

(Rac)-Cemsidomide

Product Sizes
10 mg
£ POA
HY-144841A-10MG
5 mg
£ POA
HY-144841A-5MG
10mM/1mL
£ POA
HY-144841A-10MM
About this Product
SKU:
HY-144841A
Additional Names:
(Rac)-CFT7455
Application:
Antibody Microarray
CAS Number:
2504233-68-3
Extra Details:
(Rac)-Cemsidomide ((Rac)-CFT7455) is the racemate of Cemsidomide (HY-144841) with antitumor activity[1]. Cemsidomide is a ubiquitin ligase pathway Ikaros/Aiolos degrader with molecular glue activity. Cemsidomide has a GI50 of 0.05 nM for NCIH929.1 cells.
Molecular Weight:
469.53
Purity:
98.52
References:
[1]David Proia et al. Advantageous therapies for disorders mediated by ikaros or aiolos. WO2022032132A1 (compound 5)|[2]James A. Henderson, et al. Abstract LB007: CFT7455: A novel, IKZF1/3 degrader that demonstrates potent tumor regression in IMiD-resistant multiple myeloma (MM) xenograft models. Cancer Res (2021) 81 (13_Supplement): LB007.
Research Area:
Cancer
Shipping Conditions:
Ambient
Storage Conditions:
-20[o]C; 3 years; 4[o]C; 2 years (Powder)
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
Pathway:
PROTAC
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