(4S)-PROTAC SOS1 degrader-1 (diTFA)
Product Sizes
25 mg
£ POA
HY-144657A-25MG
100 mg
£ POA
HY-144657A-100MG
10 mg
£ POA
HY-144657A-10MG
1 mg
£ POA
HY-144657A-1MG
50 mg
£ POA
HY-144657A-50MG
5 mg
£ POA
HY-144657A-5MG
10mM/1mL
£ POA
HY-144657A-10MM
About this Product
- SKU:
- HY-144657A
- Extra Details:
- (4S)-PROTAC SOS1 degrader-1 (diTFA) is a potent PROTAC SOS1 degrader. (4S)-PROTAC SOS1 degrader-1 (diTFA) decreases the expression of pERK and RAS-GTP level in a dose-dependent manner. (4S)-PROTAC SOS1 degrader-1 (diTFA) significantly inhibits the tumor growth in vivo[1].
- Molecular Weight:
- 1279.84
- Purity:
- 98.09
- References:
- [1]Zhou C,et al. Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations. J Med Chem. 2022; 65(5):3923-3942.
- Research Area:
- Cancer
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C (Powder; sealed storage; away from moisture and light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- GPCR/G Protein;MAPK/ERK Pathway;PROTAC
