Camidanlumab tesirine
Product Sizes
25 mg
HY-141599-25MG
10 mg
HY-141599-10MG
5 mg
HY-141599-5MG
1 mg
HY-141599-1MG
About this Product
- SKU:
- HY-141599
- Additional Names:
- ADCT 301
- Application:
- Antibody Microarray
- CAS Number:
- 1853239-04-9
- Extra Details:
- Camidanlumab tesirine (ADCT 301) is an ADC comprising HuMax-TAC; a human IgG1 mAb directed against human CD25; stochastically conjugated through a dipeptide cleavable linker to a pyrrolobenzodiazepine (PBD) dimer warhead. Camidanlumab tesirine has a drug–antibody ratio (DAR) of 2.3. Camidanlumab tesirine binds human CD25 with picomolar affinity. Camidanlumab tesirine has highly potent and selective cytotoxicity against a panel of CD25-expressing human lymphoma cell lines[1].
- Purity:
- 96.52
- References:
- [1]Michael J Flynn, et al. ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody-Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies. Mol Cancer Ther. 2016 Nov;15(11):2709-2721.|[2]Francesca Zammarchi, et al. CD25-targeted antibody-drug conjugate depletes regulatory T cells and eliminates established syngeneic tumors via antitumor immunity. J Immunother Cancer. 2020 Sep;8(2):e000860.
- Research Area:
- Cancer
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- -80[o]C; protect from light
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
