(2S;3S;11bR)-Dihydrotetrabenazine
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HY-141554A-1EACH
About this Product
- SKU:
- HY-141554A
- Additional Names:
- (2S;3S;11bR)-DHTBZ
- CAS Number:
- 862377-27-3
- Extra Details:
- (2S;3S;11bR)-Dihydrotetrabenazine ((2S;3S;11bR)-DHTBZ) is a highly selective inhibitor of vesicular monoamine transporter 2 (VMAT2) with a Ki value of 593 nM. (2S;3S;11bR)-Dihydrotetrabenazine inhibits vesicular transport of monoamine neurotransmitters like dopamine and serotonin; reducing their synaptic release. (2S;3S;11bR)-Dihydrotetrabenazine is promising for research of Huntington's chorea and other hyperkinetic disorders[1].
- Molecular Weight:
- 319.44
- References:
- [1]Yao Z, et al. Preparation and evaluation of tetrabenazine enantiomers and all eight stereoisomers of dihydrotetrabenazine as VMAT2 inhibitors. Eur J Med Chem. 2011 May;46(5):1841-8.
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
