(Rac)-PROTAC PARP/EGFR ligand 1
Product Sizes
Get quote
£ POA
HY-141486-1EACH
About this Product
- SKU:
- HY-141486
- Application:
- Antibody Microarray
- CAS Number:
- 2935073-36-0
- Extra Details:
- (Rac)-PROTAC PARP/EGFR ligand 1 incorporates a ligand for PARP and EGFR ; and a PROTAC linker; which recruit E3 ligases (such as VHL; CRBN; MDM2; and IAP). (Rac)-PROTAC PARP/EGFR ligand 1 can be used in the synthesis of DP-C-4; which is CRBN-based dual PROTAC for simultaneous degradation of EGFR and PARP[1]. (Rac)-PROTAC PARP/EGFR ligand 1 is a click chemistry reagent; it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Molecular Weight:
- 1020.52
- References:
- [1]Mengzhu Zheng, et al. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. J Med Chem. 2021 May 26.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
