GSK189254A
Product Sizes
100 mg
£ POA
HY-14111-100MG
10 mg
£ POA
HY-14111-10MG
50 mg
£ POA
HY-14111-50MG
5 mg
£ POA
HY-14111-5MG
1 mg
£ POA
HY-14111-1MG
10mM/1mL
£ POA
HY-14111-10MM
25 mg
£ POA
HY-14111-25MG
About this Product
- SKU:
- HY-14111
- Additional Names:
- GSK189254 (free base)
- CAS Number:
- 720690-73-3
- Extra Details:
- GSK189254A (GSK189254 free base) is a novel; potent and selective histamine H3 receptor antagonist with pKi values of 9.59-9.90 and 8.51-9.17 for human and rat H3; respectively.
- Molecular Weight:
- 351.44
- Purity:
- 98.59
- References:
- [1]Medhurst AD, et al. GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models. J Pharmacol Exp Ther. 2007 Jun;321(3):1032-45.|[2]Guo RX, et al. Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice.Br J Pharmacol. 2009 May;157(1):104-17.
- Research Area:
- Neurological Disease; Endocrinology
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
