(rel)-ML-SI3
Product Sizes
100 mg
£ POA
HY-139426A-100MG
25 mg
£ POA
HY-139426A-25MG
50 mg
£ POA
HY-139426A-50MG
10 mg
£ POA
HY-139426A-10MG
5 mg
£ POA
HY-139426A-5MG
10mM/1mL
£ POA
HY-139426A-10MM
About this Product
- SKU:
- HY-139426A
- Additional Names:
- trans-ML-SI3
- Application:
- Antibody Microarray
- CAS Number:
- 2108567-79-7
- Extra Details:
- (rel)-ML-SI3 is one of the active ingredients of ML-SI3 (HY-139426) (another component is (cis)-ML-SI3) that targets three isoforms of TRPML. (rel)-ML-SI3 is an inhibitor of TRPML1 and TRPML3 (IC50=3.1 μM/28.5 μM); and a potent activator of TRPML2 (EC50=3.3 μM)[1][2][3].
- Molecular Weight:
- 429.58
- Purity:
- 98.94
- References:
- [1]Rühl P, et al. Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors. Sci Rep. 2021 Apr 15;11(1):8313. [Content Brief]|[2]Xing Y, et al. Blunting TRPML1 channels protects myocardial ischemia/reperfusion injury by restoring impaired cardiomyocyte autophagy. Basic Res Cardiol. 2022 Apr 7;117(1):20. [Content Brief]|[3]Leser C, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021 Jan 15;210:112966.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; protect from light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Autophagy;Membrane Transporter/Ion Channel;Neuronal Signaling
