BSJ-4-116
Product Sizes
100 mg
£ POA
HY-139039-100MG
5 mg
£ POA
HY-139039-5MG
25 mg
£ POA
HY-139039-25MG
10 mg
£ POA
HY-139039-10MG
50 mg
£ POA
HY-139039-50MG
1 mg
£ POA
HY-139039-1MG
10mM/1mL
£ POA
HY-139039-10MM
About this Product
- SKU:
- HY-139039
- CAS Number:
- 2519823-34-6
- Extra Details:
- BSJ-4-116 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. BSJ-4-116 downregulates DDR genes through a premature termination of transcription; primarily through increasing poly(adenylation). BSJ-4-116 exhibits potent antiproliferative effects; alone and in combination with the poly(ADP-ribose) polymerase inhibitor Olaparib (HY-10162)[1].
- Molecular Weight:
- 837.38
- Purity:
- 99.87
- References:
- [1]Jiang B, et al. Discovery and resistance mechanism of a selective CDK12 degrader. Nat Chem Biol. 2021;17(6):675-683.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Cell Cycle/DNA Damage;PROTAC
