(E/Z)-J147
Product Sizes
10 mg
£ POA
HY-13779-10MG
50 mg
£ POA
HY-13779-50MG
5 mg
£ POA
HY-13779-5MG
25 mg
£ POA
HY-13779-25MG
100 mg
£ POA
HY-13779-100MG
500 mg
£ POA
HY-13779-500MG
10mM/1mL
£ POA
HY-13779-10MM
About this Product
- SKU:
- HY-13779
- CAS Number:
- 1146963-51-0
- Extra Details:
- (E/Z)-J147 is an exceptionally potent; orally active; neuroprotective agent for cognitive enhancement. (E/Z)-J147 can readily pass the blood brain barrier (BBB). (E/Z)-J147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter with EC50 values of 1.88 μM and 0.649 μM; respectively. (E/Z)-J147 has potential for the study of Alzheimer’s disease (AD)[1][2][3].
- Molecular Weight:
- 350.34
- Purity:
- 99.54
- References:
- [1]Wang M, et al. The first synthesis of [11C]J147, a new potential PET agent for imaging of Alzheimer's disease. Bioorg Med Chem Lett. 2013 Jan 15;23(2):524-7.|[2]Chen Q, et al. A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. PLoS One. 2011;6(12):e27865.|[3]Prior M, et al. Selecting for neurogenic potential as an alternative for Alzheimer's disease drug discovery. Alzheimers Dement. 2016 Jun;12(6):678-86.|[4]Prior M, et al. The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. Alzheimers Res Ther. 2013 May 14;5(3):25.
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Neuronal Signaling
