SK-3-91
Product Sizes
100 mg
£ POA
HY-137341-100MG
25 mg
£ POA
HY-137341-25MG
10 mg
£ POA
HY-137341-10MG
50 mg
£ POA
HY-137341-50MG
5 mg
£ POA
HY-137341-5MG
10mM/1mL
£ POA
HY-137341-10MM
About this Product
- SKU:
- HY-137341
- CAS Number:
- 2769753-23-1
- Extra Details:
- SK-3-91 is a PROTAC-type multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases). SK-3-91 induces protein degradation through the ubiquitin biotinylation (E-STUB) pathway. SK-3-91 degrades YTHDF2. SK-3-91 inhibits cell proliferation and induces morphological changes. (Pink: TAE648 ligand (HY-169396); Blue: E3 ligase ligand (HY-131717); Black: Linker (HY-140819). The E3 ligase ligand and linker can form a conjugate (HY-169397))[1][2].
- Molecular Weight:
- 887.40
- Purity:
- 98.33
- References:
- [1]Donovan KA, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 Dec 10;183(6):1714-1731.e10.|[2]Goebel GL, et al. Profiling Cellular Morphological Changes Induced by Dual-Targeting PROTACs of Aurora Kinase and RNA-Binding Protein YTHDF2. Chembiochem. 2024 Oct 1;25(19):e202400183.
- Research Area:
- Cancer
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C (Powder; protect from light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Epigenetics;PROTAC
