PQ401
Product Sizes
10 mg
£ POA
HY-13686-10MG
5 mg
£ POA
HY-13686-5MG
50 mg
£ POA
HY-13686-50MG
10mM/1mL
£ POA
HY-13686-10MM
25 mg
£ POA
HY-13686-25MG
100 mg
£ POA
HY-13686-100MG
About this Product
- SKU:
- HY-13686
- CAS Number:
- 196868-63-0
- Extra Details:
- PQ401 is a potent inhibitor of IGF-IR signaling. PQ401 inhibits IGF-I-stimulated IGF-IR autophosphorylation with an IC50 of 12.0 μM in a series of studies in MCF-7 cells. PQ401 is effective at inhibiting IGF-I-stimulated growth of MCF-7 cells (IC50; 6 μM). PQ401 is a potential agent for breast and other IGF-I-sensitive cancers. PQ401 induces caspase-mediated apoptosis[1].
- Molecular Weight:
- 341.79
- Purity:
- 99.92
- References:
- [1]Gable KL, Maddux BA, Penaranda C, Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. Mol Cancer Ther. 2006 Apr;5(4):1079-86.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Apoptosis;Protein Tyrosine Kinase/RTK
