(1S;9R)-Exatecan (mesylate)
Product Sizes
10 mg
£ POA
HY-13631I-10MG
5 mg
£ POA
HY-13631I-5MG
50 mg
£ POA
HY-13631I-50MG
25 mg
£ POA
HY-13631I-25MG
100 mg
£ POA
HY-13631I-100MG
10mM/1mL
£ POA
HY-13631I-10MM
About this Product
- SKU:
- HY-13631I
- Additional Names:
- (1S;9R)-DX8951f
- Application:
- Antibody Microarray
- CAS Number:
- 2938875-54-6
- Extra Details:
- (1S;9R)-Exatecan mesylate ((1S;9R)-DX8951f) is a non-prodrug camptothecin derivative and a topoisomerase I inhibitor (IC50=0.975 μg/mL in mice and 0.82 μg/mL in humans). (1S;9R)-Exatecan mesylate blocks enzyme activity and induces apoptosis by stabilizing the enzyme-DNA cleavable complex. (1S;9R)-Exatecan mesylate not only effectively inhibits the proliferation of various malignant tumor cells and tumor growth; but also circumvents P-glycoprotein-mediated multidrug resistance. (1S;9R)-Exatecan mesylate is widely used in preclinical studies of various cancers such as pancreatic cancer; lung cancer; breast cancer; and leukemia[1][2].The chiral isomer of (1S;9R)-Exatecan mesylate is (1R;9R)-Exatecan mesylate (HY-13631J).
- Molecular Weight:
- 531.55
- Purity:
- 98.48
- References:
- [1]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; sealed storage; away from moisture and light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage
