10;12-Tricosadiynoic acid
Product Sizes
100 mg
£ POA
HY-135425-100MG
10 mg
£ POA
HY-135425-10MG
50 mg
£ POA
HY-135425-50MG
25 mg
£ POA
HY-135425-25MG
5 mg
£ POA
HY-135425-5MG
10mM/1mL
£ POA
HY-135425-10MM
About this Product
- SKU:
- HY-135425
- Application:
- Immunoprecipitation
- CAS Number:
- 66990-30-5
- Extra Details:
- 10;12-Tricosadiynoic acid is a highly specific; selective; high affinity and orally active acyl-CoA oxidase-1 (ACOX1) inhibitor. 10;12-Tricosadiynoic acid can treat high fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS metabolism[1]. 10;12-Tricosadiynoic acid is a click chemistry reagent; it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Molecular Weight:
- 346.55
- Purity:
- 99.95
- References:
- [1]Zeng J, et al. Specific Inhibition of Acyl-CoA Oxidase-1 by an Acetylenic Acid Improves Hepatic Lipid and Reactive Oxygen Species (ROS) Metabolism in Rats Fed a High Fat Diet. J Biol Chem. 2017 Mar 3;292(9):3800-3809.|[2]Takuto Chiba, et al. Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI. J Am Soc Nephrol. 2019 Dec;30(12):2384-2398.|[3]Yan Liu, et al. Impaired peroxisomal fat oxidation induces hepatic lipid accumulation and oxidative damage in Nile tilapia. Fish Physiol Biochem. 2020 Aug;46(4):1229-1242.
- Research Area:
- Metabolic Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; protect from light; stored under nitrogen)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Metabolic Enzyme/Protease
