Emavusertib (mesylate)
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HY-135317D-1EACH
About this Product
- SKU:
- HY-135317D
- Additional Names:
- CA-4948 (mesylate)
- CAS Number:
- 2376399-40-3
- Extra Details:
- Emavusertib mesylate (CA-4948 mesylate) is the mesylate salt form of Emavusertib (HY-135317). Emavusertib mesylate is an orally active inhibitor for IRAK4 (IC50=57 nM) and FLT3. Emavusertib mesylate inhibits NF-κB and MyD88 signaling pathways; reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10; thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells; leading to cell apoptosis. Emavusertib mesylate exhibits antitumor activity in mouse model[1][2][3].
- Molecular Weight:
- 587.60
- References:
- [1]Wiese MD, et al. Investigational IRAK-4 inhibitors for the treatment of rheumatoid arthritis. Expert Opin Investig Drugs. 2020 Apr 17:1-8.|[2]Guidetti F, et al. Targeting IRAK4 with Emavusertib in Lymphoma Models with Secondary Resistance to PI3K and BTK Inhibitors. J Clin Med. 2023 Jan 4;12(2):399. |[3]Parrondo RD, et al. IRAK-4 inhibition: emavusertib for the treatment of lymphoid and myeloid malignancies. Front Immunol. 2023 Oct 26;14:1239082.
- Research Area:
- Cancer; Inflammation/Immunology
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
