INCB086550
Product Sizes
10 mg
£ POA
HY-134884-10MG
25 mg
£ POA
HY-134884-25MG
50 mg
£ POA
HY-134884-50MG
5 mg
£ POA
HY-134884-5MG
100 mg
£ POA
HY-134884-100MG
About this Product
- SKU:
- HY-134884
- Additional Names:
- PD-1/PD-L1-IN-8
- Application:
- Antibody Microarray
- CAS Number:
- 2230911-59-6
- Extra Details:
- INCB086550 is a potent; oral; small-molecule PD-L1 inhibitor with IC50s value of 3.1; 4.9 and 1.9 nM for human; cynomolgus; and rat; respectively. INCB086550 promotes the dimerization of cell-surface PD-L1 and induces PD-L1 entry into Golgi vesicles then traffick to the nucleus. INCB086550 can be used for multiple cancers research[1].
- Molecular Weight:
- 693.79
- Purity:
- 99.80
- References:
- [1]WU LIANGXING, et al. BENZOOXAZOLE DERIVATIVES AS IMMUNOMODULATORS. WO2018119266A1.|[2]Koblish HK, et al. Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor. Cancer Discov. 2022 Jun 2;12(6):1482-1499.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Immunology/Inflammation
