HG-10-102-01
Product Sizes
50 mg
£ POA
HY-13488-50MG
10 mg
£ POA
HY-13488-10MG
5 mg
£ POA
HY-13488-5MG
25 mg
£ POA
HY-13488-25MG
10mM/1mL
£ POA
HY-13488-10MM
100 mg
£ POA
HY-13488-100MG
About this Product
- SKU:
- HY-13488
- CAS Number:
- 1351758-81-0
- Extra Details:
- HG-10-102-01 is a highly potent; selective; and brain-penetrable LRRK2 inhibitor; with IC50 values of 20.3 and 3.2 nM against wild-type LRRK2 and LRRK2[G2019S]; respectively. HG-10-102-01 also inhibits MNK2 and MLK1; with IC50 values of 0.6 and 2.1 μM. HG-10-102-01 can be used for Parkinson's disease (PD) research[1][2].
- Molecular Weight:
- 377.83
- Purity:
- 99.55
- References:
- [1]Choi HG, et al. Brain Penetrant LRRK2 Inhibitor. ACS Med Chem Lett. 2012 Aug 9;3(8):658-662.|[2]Wang M, et al. Synthesis of [11C]HG-10-102-01 as a new potential PET agent for imaging of LRRK2 enzyme in Parkinson's disease. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1351-1355.
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Autophagy;MAPK/ERK Pathway
