KU-0060648
Product Sizes
25 mg
£ POA
HY-13431-25MG
5 mg
£ POA
HY-13431-5MG
10 mg
£ POA
HY-13431-10MG
1 mg
£ POA
HY-13431-1MG
50 mg
£ POA
HY-13431-50MG
100 mg
£ POA
HY-13431-100MG
About this Product
- SKU:
- HY-13431
- CAS Number:
- 881375-00-4
- Extra Details:
- KU-0060648 is a dual inhibitor of PI3K and DNA-PK with IC50s of 4 nM; 0.5 nM; 0.1 nM; 0.594 nM and 8.6 nM for PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ and DNA-PK; respectively[1].
- Molecular Weight:
- 582.71
- Purity:
- 99.87
- References:
- [1]Munck JM, et al. Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K. Mol Cancer Ther. 2012 Aug;11(8):1789-98.|[2]Chen MB, et al. KU-0060648 inhibits hepatocellular carcinoma cells through DNA-PKcs-dependent and DNA-PKcs-independent mechanisms. Oncotarget. 2016 Mar 29;7(13):17047-59.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Cell Cycle/DNA Damage;PI3K/Akt/mTOR
