Inotersen (sodium)
Product Sizes
5 mg
£ POA
HY-132608-5MG
1 mg
£ POA
HY-132608-1MG
10 mg
£ POA
HY-132608-10MG
100 mg
£ POA
HY-132608-100MG
50 mg
£ POA
HY-132608-50MG
25 mg
£ POA
HY-132608-25MG
About this Product
- SKU:
- HY-132608
- Additional Names:
- ISIS-420915 (sodium)
- CAS Number:
- 1432726-13-0
- Extra Details:
- Inotersen (ISIS-420915) sodium is a 2′-O-methoxyethyl-modified antisense oligonucleotide. Inotersen sodium inhibits the production of transthyretin (TTR) protein by targeting the TTR RNA transcript and reduces the levels of the TTR transcript. Inotersen sodium can be used for the research of hereditary TTR amyloidosis polyneuropathy[1][2][3].
- Molecular Weight:
- 7183.08 (free acid)
- Purity:
- 96.44
- References:
- [1]Ackermann EJ, et, al. Suppressing transthyretin production in mice, monkeys and humans using 2nd-Generation antisense oligonucleotides. Amyloid. 2016 Sep;23(3):148-157.|[2]Mathew V, et, al. Inotersen: new promise for the treatment of hereditary transthyretin amyloidosis. Drug Des Devel Ther. 2019 May 6;13:1515-1525.|[3]Benson MD, et, al. Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis. N Engl J Med. 2018 Jul 5;379(1):22-31.
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C (Powder; sealed storage; away from moisture)
- Type:
- Molecular Biology Reagents: Nucleic Acids
- Pathway:
- Neuronal Signaling
