PROTAC PD-1/PD-L1 degrader-1
Product Sizes
5 mg
£ POA
HY-131183-5MG
50 mg
£ POA
HY-131183-50MG
1 mg
£ POA
HY-131183-1MG
100 mg
£ POA
HY-131183-100MG
25 mg
£ POA
HY-131183-25MG
10 mg
£ POA
HY-131183-10MG
10mM/1mL
£ POA
HY-131183-10MM
About this Product
- SKU:
- HY-131183
- CAS Number:
- 2447066-37-5
- Extra Details:
- PROTAC PD-1/PD-L1 degrader-1; a PD-1/PD-L1 PROTAC based on Cereblon E3 ligand; inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM. PROTAC PD-1/PD-L1 degrader-1 significantly restores the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. PROTAC PD-1/PD-L1 degrader-1 moderately reduces the protein levels of PD-L1 in a lysosome-dependent manner[1].
- Molecular Weight:
- 1076.59
- Purity:
- 99.52
- References:
- [1]Cheng B, Ren Y, Cao H, Chen J. Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1. Eur J Med Chem. 2020;199:112377.
- Research Area:
- Inflammation/Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C (Powder; sealed storage; away from moisture and light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Immunology/Inflammation;PROTAC
