1-Naphthohydroxamic acid
Product Sizes
5 mg
£ POA
HY-130538-5MG
50 mg
£ POA
HY-130538-50MG
10 mg
£ POA
HY-130538-10MG
100 mg
£ POA
HY-130538-100MG
10mM/1mL
£ POA
HY-130538-10MM
About this Product
- SKU:
- HY-130538
- Application:
- Antibody Microarray
- CAS Number:
- 6953-61-3
- Extra Details:
- 1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity[1][2].1-Naphthohydroxamic acid can induce tubulin acetylation[3].
- Molecular Weight:
- 187.19
- Purity:
- 99.59
- References:
- [1]Krennhrubec K, et al. Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8.|[2]Oehme I, et al. Histone deacetylase 8 in neuroblastoma tumorigenesis. Clin Cancer Res. 2009 Jan 1;15(1):91-9.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Cell Cycle/DNA Damage;Epigenetics
