(+)-JQ-1
Product Sizes
50 mg
£ POA
HY-13030-50MG
5 mg
£ POA
HY-13030-5MG
500 mg
£ POA
HY-13030-500MG
2 mg
£ POA
HY-13030-2MG
10 mg
£ POA
HY-13030-10MG
100 mg
£ POA
HY-13030-100MG
10mM/1mL
£ POA
HY-13030-10MM
25 mg
£ POA
HY-13030-25MG
About this Product
- SKU:
- HY-13030
- Additional Names:
- JQ1
- Application:
- Antibody Microarray
- CAS Number:
- 1268524-70-4
- Extra Details:
- (+)-JQ-1 (JQ1); a chemical probe; is a potent; specific; CNS-penetrant and reversible BET bromodomain inhibitor; with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4(1/2))[1]. (+)-JQ-1 also activates autophagy[2].
- Molecular Weight:
- 456.99
- Purity:
- 99.90
- References:
- [1]Filippakopoulos P, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.|[2]Sakamaki JI, et al. Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and LysosomalFunction. Mol Cell. 2017 May 18;66(4):517-532.e9.|[3]Matzuk MM, et al. Small-molecule inhibition of BRDT for male contraception. Cell. 2012 Aug 17;150(4):673-84.
- Research Area:
- Cancer;Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Autophagy;Epigenetics;PROTAC
