(S)-GNE-987
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HY-129937-1EACH
About this Product
- SKU:
- HY-129937
- Application:
- Antibody Microarray
- CAS Number:
- 2738533-33-8
- Extra Details:
- (S)-GNE-987 (compound 4); the GNE-987 (a chimeric BET degrader) hydroxy-proline epimer; abrogates binding to von Hippel-Lindau and does not degrade BRD4 protein. (S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC)[1].
- Molecular Weight:
- 1096.31
- References:
- [1]Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
