CL2 Linker
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HY-128947-1EACH
About this Product
- SKU:
- HY-128947
- Application:
- Antibody Microarray
- CAS Number:
- 2270986-66-6
- Extra Details:
- CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in agent substitution (~6); cell binding (Kd ~1.2 nM); cytotoxicity (IC50 ~2.2 nM); and serum stability in vitro (t1/2 ~20 hours)[1][2].
- Molecular Weight:
- 1426.61
- References:
- [1]Moon SJ, et al. Antibody conjugates of 7-ethyl-10-hydroxycamptothecin (SN-38) for targeted cancer chemotherapy. J Med Chem. 2008 Nov 13;51(21):6916-26.|[2]Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
