CL2A-SN-38
Product Sizes
50 mg
£ POA
HY-128946-50MG
1 mg
£ POA
HY-128946-1MG
5 mg
£ POA
HY-128946-5MG
100 mg
£ POA
HY-128946-100MG
10 mg
£ POA
HY-128946-10MG
25 mg
£ POA
HY-128946-25MG
About this Product
- SKU:
- HY-128946
- Application:
- Antibody Microarray
- CAS Number:
- 1279680-68-0
- Extra Details:
- CL2A-SN-38 is a agent-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody agent conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A-SN-38 uses hydrolyzable linker to deliver active agents within tumor cells and in the tumor microenvironment; resulting in bystander effects[1].
- Molecular Weight:
- 1480.61
- Purity:
- 99.97
- References:
- [1]Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69.|[2]Thomas M Cardillo, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69.
- Research Area:
- Cancer; Inflammation/Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C (Powder; stored under nitrogen)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Conjugated Protein
- Pathway:
- Antibody-drug Conjugate/ADC Related
