Dooku1
Product Sizes
100 mg
£ POA
HY-126010-100MG
50 mg
£ POA
HY-126010-50MG
10 mg
£ POA
HY-126010-10MG
25 mg
£ POA
HY-126010-25MG
5 mg
£ POA
HY-126010-5MG
10mM/1mL
£ POA
HY-126010-10MM
About this Product
- SKU:
- HY-126010
- CAS Number:
- 2253744-54-4
- Extra Details:
- Dooku1 is a reversibly Yoda1 antagonist with IC50 value of 1.3 μM and 1.5 μM for 2 μM Yoda1-induced Ca2+ entry HEK 293 cells and HUVECs; respectively. Dooku1 can disrupt Yoda1-induced Piezo1 channel activity and inhibit Yoda1-induced relaxation of aorta. Dooku1 can be used for vascular physiology and disease research[1].
- Molecular Weight:
- 326.20
- Purity:
- 99.93
- References:
- [1]Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175(10):1744-1759.|[2]Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175(10):1744-1759.
- Research Area:
- Others
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C (Powder; sealed storage; away from moisture)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Membrane Transporter/Ion Channel
