QM31
Product Sizes
100 mg
£ POA
HY-125018-100MG
50 mg
£ POA
HY-125018-50MG
10 mg
£ POA
HY-125018-10MG
5 mg
£ POA
HY-125018-5MG
25 mg
£ POA
HY-125018-25MG
10mM/1mL
£ POA
HY-125018-10MM
About this Product
- SKU:
- HY-125018
- Additional Names:
- SVT016426
- Application:
- Antibody Microarray
- CAS Number:
- 937735-00-7
- Extra Details:
- QM31 (SVT016426); a cytoprotective agent; is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9μM); the caspase activation complex composed by Apaf-1; cytochrome c; dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint[1][2].
- Molecular Weight:
- 768.56
- Purity:
- 95.00
- References:
- [1]Mondragón L, et al. A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint. Apoptosis. 2009 Feb;14(2):182-90.|[2]Orzáez M, et al. Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity. PLoS One. 2014 Oct 20;9(10):e110979.|[3]Gortat A, et al. Apaf1 inhibition promotes cell recovery from apoptosis. Protein Cell. 2015 Nov;6(11):833-43.
- Research Area:
- Cancer
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C; 3 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Apoptosis
