ENMD-1068 (hydrochloride)
Product Sizes
5 mg
£ POA
HY-124748A-5MG
50 mg
£ POA
HY-124748A-50MG
10 mg
£ POA
HY-124748A-10MG
25 mg
£ POA
HY-124748A-25MG
10mM/1mL
£ POA
HY-124748A-10MM
About this Product
- SKU:
- HY-124748A
- CAS Number:
- 2703451-51-6
- Extra Details:
- ENMD-1068 hydrochloride is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 hydrochloride reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 hydrochloride also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 hydrochloride can be used in the study of endometriosis and liver fibrosis[1][2].
- Molecular Weight:
- 319.87
- Purity:
- 98.33
- References:
- [1]Sun Q, et al. ENMD-1068 inhibits liver fibrosis through attenuation of TGF-β1/Smad2/3 signaling in mice. Sci Rep. 2017 Jul 14;7(1):5498. doi: 10.1038/s41598-017-05190-7. Erratum in: Sci Rep. 2019 Dec 10;9(1):19125. |[2]Wang Y, et al. ENMD-1068, a protease-activated receptor 2 antagonist, inhibits the development of endometriosis in a mouse model. Am J Obstet Gynecol. 2014 Jun;210(6):531.e1-8.
- Research Area:
- Inflammation/Immunology
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; stored under nitrogen)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Apoptosis;GPCR/G Protein
