(R)-(+)-Mequitazine
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HY-124626-1EACH
About this Product
- SKU:
- HY-124626
- CAS Number:
- 147780-50-5
- Extra Details:
- (R)-(+)-Mequitazine is a histamine H1 receptor antagonist that mainly undergoes bio-transformation via human liver microsomes; resulting in hydroxylated and S-oxidized metabolites. (R)-(+)-Mequitazine competitively binds to the H1 receptors in gastrointestinal; vascular; and respiratory effect cells; thus blocking the endogenous activity of histamine. (R)-(+)-Mequitazine has an inhibitory effect on CYP3A-catalyzed midazolam 1’-hydroxylase. (R)-(+)-Mequitazine can be used in the study of various allergic diseases[1][2].
- Molecular Weight:
- 322.47
- References:
- [1]Jeong SH, et al. A novel and sensitive UPLC-MS/MS method to determine mequitazine in rat plasma and urine: Validation and its application to pharmacokinetic studies. Biomed Chromatogr. 2019 Oct;33(10):e4627.|[2]Nakamura K, et al. Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes. J Pharmacol Exp Ther. 1998 Feb;284(2):437-42. PMID: 9454781.
- Research Area:
- Inflammation/Immunology
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
