GPI-1046
Product Sizes
5 mg
£ POA
HY-124619-5MG
25 mg
£ POA
HY-124619-25MG
10 mg
£ POA
HY-124619-10MG
50 mg
£ POA
HY-124619-50MG
10mM/1mL
£ POA
HY-124619-10MM
About this Product
- SKU:
- HY-124619
- CAS Number:
- 186452-09-5
- Extra Details:
- GPI-1046 is an orally active; antibiotic-free immunophilin ligand that reduces ethanol intake by upregulating glutamate transporter 1 (GLT1) in the prefrontal cortex (PFC) and nucleus accumbens core (NAc-core). GPI-1046 improves human immunodeficiency virus (HIV)-associated sensory neuropathy (HIV-SN) by attenuating store-operated calcium (SOC) entry. GPI-1046 has neuroprotective activity[1][2][3].
- Molecular Weight:
- 360.45
- Purity:
- 99.79
- References:
- [1]Sari Y, et al. Neuroimmunophilin GPI-1046 reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats. Neuroscience. 2012 Dec 27;227:327-35.|[2]Höke A, et al. GPI-1046 protects dorsal root ganglia from gp120-induced axonal injury by modulating store-operated calcium entry. J Peripher Nerv Syst. 2009 Mar;14(1):27-35.|[3]Ganel R, et al. Selective up-regulation of the glial Na+-dependent glutamate transporter GLT1 by a neuroimmunophilin ligand results in neuroprotection. Neurobiol Dis. 2006 Mar;21(3):556-67.
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; protect from light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Anti-infection;Membrane Transporter/Ion Channel
