12(R)-HETE
Product Sizes
10 μg (312.04 μM * 100 μL in Ethanol)
HY-124404-10UG
50 μg (312.04 μM * 500 μL in Ethanol)
HY-124404-50UG
25 μg (312.04 μM * 250 μL in Ethanol)
HY-124404-25UG
5 μg (312.04 μM * 50 μL in Ethanol)
HY-124404-5UG
About this Product
- SKU:
- HY-124404
- CAS Number:
- 82337-46-0
- Extra Details:
- 12(R)-HETE is a CYP-dependent arachidonic acid metabolite that acts as a proinflammatory lipid mediator. 12 (R)-HETE widely exists in various tissues including the eye; skin and liver. In the cornea; 12(R)-HETE is metabolized via pathways such as β-oxidation into the precursor of 12(R)-HETrE. Without direct receptor binding; 12(R)-HETE indirectly activates AHR-mediated target gene transcription; while inhibiting the enzymatic activity of Na+;K+-ATPase and the intracellular calcium elevation induced by TP agonists. 12(R)-HETE also possesses multiple physiological effects such as chemotaxis; proangiogenesis; vasodilation; natriuresis; diuresis and intraocular pressure reduction; and can be widely used in studies related to psoriasis; inflammatory skin diseases and ocular inflammation[1][2][3].
- Molecular Weight:
- 320.47
- Purity:
- 99.90
- Research Area:
- Inflammation/Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Solution; -20[o]C; 2 years
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
