(3S;5S;6R)-Navtemadlin
Product Sizes
10 mg
£ POA
HY-12296A-10MG
100 mg
£ POA
HY-12296A-100MG
25 mg
£ POA
HY-12296A-25MG
5 mg
£ POA
HY-12296A-5MG
50 mg
£ POA
HY-12296A-50MG
10mM/1mL
£ POA
HY-12296A-10MM
About this Product
- SKU:
- HY-12296A
- Additional Names:
- (3S;5S;6R)-AMG 232; (3S;5S;6R)-KRT-232
- Application:
- Antibody Microarray
- CAS Number:
- 2459946-14-4
- Extra Details:
- (3S;5S;6R)-Navtemadlin is the isomer of Navtemadlin (HY-12296); and can be used as an experimental control. Navtemadlin (AMG 232) is a potent; selective and orally available inhibitor of p53-MDM2 interaction; with an IC50 of 0.6 nM. Navtemadlin binds to MDM2 with a Kd of 0.045 nM[1][2].
- Molecular Weight:
- 568.55
- Purity:
- 99.60
- References:
- [1]Canon J, et al. The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents. Mol Cancer Ther. 2015 Mar;14(3):649-58.|[2]Rew Y, et al. Discovery of a small molecule MDM2 inhibitor (AMG 232) for treating cancer. J Med Chem. 2014 Aug 14;57(15):6332-41.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Apoptosis
