(S)-Laudanosine
Product Sizes
1 mg
£ POA
HY-122489A-1MG
5 mg
£ POA
HY-122489A-5MG
About this Product
- SKU:
- HY-122489A
- CAS Number:
- 2688-77-9
- Extra Details:
- (S)-Laudanosine is an alkaloid that can be found in poppies and is the S-enantiomer of Laudanosine. Laudanosine acts on the central nervous system and cardiovascular system; inhibiting low-affinity GABA receptors with an IC50 value of 10 μM; and can cause seizures; hypotension; and bradycardia. Additionally; Laudanosine exerts analgesic effects by competitively binding to the opioid Mu-1 receptor (Ki = 2.7 μM)[1][2][3][4].
- Molecular Weight:
- 357.44
- Purity:
- 99.95
- References:
- [1]Fodale V, et al. Laudanosine, an atracurium and cisatracurium metabolite[J]. European journal of anaesthesiology, 2002, 19(7): 466-473.|[2]Katz Y, et al. Interactions between laudanosine, GABA, and opioid subtype receptors: implication for laudanosine seizure activity. Brain Res. 1994 May 23;646(2):235-41.|[3]Chuliá S, et al. Mechanism of the cardiovascular activity of laudanosine: comparison with papaverine and other benzylisoquinolines. Br J Pharmacol. 1994 Dec;113(4):1377-85.|[4]Chapple DJ, et al. Cardiovascular and neurological effects of laudanosine. Studies in mice and rats, and in conscious and anaesthetized dogs. Br J Anaesth. 1987 Feb;59(2):218-25.
- Research Area:
- Neurological Disease; Cardiovascular Disease
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C; 3 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling
