NVP-AAD777
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HY-122010-1EACH
About this Product
- SKU:
- HY-122010
- CAS Number:
- 300842-59-5
- Extra Details:
- NVP-AAD777 is a specific inhibitor of VEGFR-2; demonstrated in vivo by its effective suppression of phospho-VEGFR-2 (Tyr1175) signaling in rat lung tissues. Unlike the nonspecific VEGFR inhibitor SUG-5416; NVP-AAD777 did not induce emphysematous changes in the lungs after three weeks of treatment; even when combined with exposure to cigarette smoke. Additionally; there were no alterations observed in vascular density compared to control animals. This indicates NVP-AAD777's targeted action in inhibiting VEGFR-2 without adverse pulmonary effects; highlighting its potential therapeutic utility in managing conditions associated with aberrant VEGFR-2 signaling[1].
- Molecular Weight:
- 448.36
- References:
- [1]Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition
- Research Area:
- others
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
