(Z)-KC02
Product Sizes
1 mg (34.80 mM * 100 μL in Ethyl acetate)
HY-121892-1MG
About this Product
- SKU:
- HY-121892
- CAS Number:
- 1646795-60-9
- Extra Details:
- (Z)-KC02 is an inhibitor of ABHD16A; the phosphatidylserine (PS) lipase that produces lyso-PS. Lysophosphatidylserine (lyso-PS) is a signaling lipid that regulates immune and neurological processes. It is associated with several neurological disorders such as retinitis pigmentosa and cataracts (PHARC). (Z)-KC02 depletes lyso-PS in lymphoblasts from PHARC subjects. (Z)-KC02 also reduces lyso-PS and lipopolysaccharide-induced cytokine production in macrophages and modulates lyso-PS metabolism in vivo[1].
- Molecular Weight:
- 287.35
- Purity:
- 99.0
- References:
- [1]Kamat SS, Camara K, Parsons WH, Chen DH, Dix MM, Bird TD, Howell AR, Cravatt BF. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. Nat Chem Biol. 2015 Feb;11(2):164-71.
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Solution; -20[o]C; 2 years
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Apoptosis
