(E)-2-Hexadecenal
Product Sizes
5 mg
£ POA
HY-121683-5MG
1 mg
£ POA
HY-121683-1MG
About this Product
- SKU:
- HY-121683
- Additional Names:
- 16:1 Aldehyde; trans-2-Hexadecenal
- CAS Number:
- 22644-96-8
- Extra Details:
- (E)-2-Hexadecenal (trans-2-Hexadecenal) is an MLK3 activator that induces cytoskeletal remodeling; leading to cell rounding; detachment; and ultimately apoptosis in human and mouse cells. (E)-2-Hexadecenal activates the MLK3 signaling pathway; phosphorylating MKK4/7 and JNK; subsequently activating downstream targets of JNK; such as c-Jun phosphorylation; cytochrome c release; Bax activation; Bid cleavage; and Bim translocation to mitochondria. (E)-2-Hexadecenal has potential applications in research related to sphingolipid signaling pathways[1].
- Molecular Weight:
- 238.41
- Purity:
- 99.9
- References:
- [1]Kumar A, et al. The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner. Cell Signal. 2011 Jul;23(7):1144-52.
- Research Area:
- Cancer
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C; 3 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
