(E/Z)-IT-603
Product Sizes
25 mg
£ POA
HY-121508-25MG
5 mg
£ POA
HY-121508-5MG
100 mg
£ POA
HY-121508-100MG
10 mg
£ POA
HY-121508-10MG
50 mg
£ POA
HY-121508-50MG
10mM/1mL
£ POA
HY-121508-10MM
About this Product
- SKU:
- HY-121508
- CAS Number:
- 292168-90-2
- Extra Details:
- (E/Z)-IT-603 is a mixture of E-IT-603 and Z-IT-603 (IT-603). (E/Z)-IT-603 is also an IĸBα/c-Rel inhibitor. IT-603 is a c-Rel inhibitor with an IC50 of 3 μM. IT-603 has anti-tumor activity. (E/Z)-IT-603 is a promising modulator of T-cell responses in the context of graft-versus-host disease (GVHD) and malignant diseases[1].
- Molecular Weight:
- 329.17
- Purity:
- 99.29
- References:
- [1]Yusuke Shono, et al. A small molecule c-Rel inhibitor reduces alloactivation of T-cells without compromising anti-tumor activity. Cancer Discov. 2014 May; 4(5): 578-591.|[2]Huang X, et al. ESAT-6 protein suppresses allograft rejection by inducing CD4+Foxp3+ regulatory T cells through IκBα/cRel pathway. Front Immunol. 2025 Jan 9;15:1529226.
- Research Area:
- Cancer; Inflammation/Immunology
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- NF-κB
