(2Z;3Z)-U0126
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HY-12031B-1EACH
About this Product
- SKU:
- HY-12031B
- CAS Number:
- 218601-62-8
- Extra Details:
- (2Z;3Z)-U0126 is a selective inhibitor of MEK1 and MEK2; demonstrating potent antiinflammatory effects by noncompetitively inhibiting AP-1 transcriptional activity with IC50 values of 72 nM for MEK1 and 58 nM for MEK2. (2Z;3Z)-U0126 also inhibits anchorage-independent growth of Ki-ras-transformed rat fibroblasts by blocking both the extracellular signal-regulated kinase and mammalian target of rapamycin pathways. Additionally; (2Z;3Z)-U0126 can undergo isomerization and cyclization; resulting in various products that show reduced affinity for MEK and diminished AP-1 inhibition compared to the parent compound.
- Molecular Weight:
- 380.49
- References:
- [1]MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products
- Research Area:
- Inflammation/Immunology
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
